Psychosocial mediators of change in physical activity in the Welsh national exercise referral scheme: secondary analysis of a randomised controlled trial

Objective: While an increasing number of randomised controlled trials report impacts of exercise referral schemes (ERS) on physical activity, few have investigated the mechanisms through which increases in physical activity are produced. This study examines whether a National Exercise Referral Scheme (NERS) in Wales is associated with improvements in autonomous motivation, self-efficacy and social support, and whether change in physical activity is mediated by change in these psychosocial processes.<p></p> Methods: A pragmatic randomised controlled trial of NERS across 12 LHBs in Wales. Questionnaires measured demographic data and physical activity at baseline. Participants (N = 2160) with depression, anxiety or CHD risk factors were referred by health professionals and randomly assigned to control or intervention. At six months psychological process measures were collected by questionnaire. At 12 months physical activity was assessed by 7 Day PAR telephone interview. Regressions tested intervention effects on psychosocial variables, physical activity before and after adjusting for mediators and socio demographic patterning.<p></p> Results: Significant intervention effects were found for autonomous motivation and social support for exercise at 6 months. No intervention effect was observed for self-efficacy. The data are consistent with a hypothesis of partial mediation of the intervention effect by autonomous motivation. Analysis of moderators showed significant improvements in relative autonomy in all subgroups. The greatest improvements in autonomous motivation were observed among patients who were least active at baseline.<p></p> Discussion: The present study offered key insights into psychosocial processes of change in an exercise referral scheme, with effects on physical activity mediated by autonomous motivation. Findings support the use of self-determination theory as a framework for ERS. Further research is required to explain socio-demographic patterning in responses to ERS, with changes in motivation occurring among all sub-groups of participants, though not always leading to higher adherence or behavioural change. This highlights the importance of socio-ecological approaches to developing and evaluating behaviour change interventions, which consider factors beyond the individual, including conditions in which improved motivation does or does not produce behavioural change

Corporate Tax Competition between Firms

Firms' tax planning decisions, similar to their other operational decisions, are made in a competitive environment. Various stakeholders observe the tax payments and evaluate these against the relevant peer group, which creates interdependencies in the tax planning activities of firms. Introducing the concept of reputational loss we show the positive interdependence in a theoretical model and test it in a spatial econometric model. Empirical evidence suggests that benchmarking takes place both within countries and within industries, however for the latter it is important to include firms in large non-EU OECD countries. Further, the analysis shows that spatial interdependence is stronger for the largest firms and if they have an average effective tax rate above the statutory tax rate.Corporate Taxation; Benchmarking; Tax Competition; Spatial Econometrics

Application of chicken microarrays for gene expression analysis in other avian species

BACKGROUND: With the threat of emerging infectious diseases such as avian influenza, whose natural hosts are thought to be a variety of wild water birds including duck, we are armed with very few genomic resources to investigate large scale immunological gene expression studies in avian species. Multiple options exist for conducting large gene expression studies in chickens and in this study we explore the feasibility of using one of these tools to investigate gene expression in other avian species. RESULTS: In this study we utilised a whole genome long oligonucleotide chicken microarray to assess the utility of cross species hybridisation (CSH). We successfully hybridised a number of different avian species to this array, obtaining reliable signals. We were able to distinguish ducks that were infected with avian influenza from uninfected ducks using this microarray platform. In addition, we were able to detect known chicken immunological genes in all of the hybridised avian species. CONCLUSION: Cross species hybridisation using long oligonucleotide microarrays is a powerful tool to study the immune response in avian species with little available genomic information. The present study validated the use of the whole genome long oligonucleotide chicken microarray to investigate gene expression in a range of avian species

Money and happiness : rank of income, not income, affects life satisfaction

Does money buy happiness, or does happiness come indirectly from the higher rank in society that money brings? Here we test a rank hypothesis, according to which people gain utility from the ranked position of their income within a comparison group. The rank hypothesis contrasts with traditional reference income hypotheses, which suggest utility from income depends on comparison to a social group reference norm. We find that the ranked position of an individual’s income predicts general life satisfaction, while absolute income and reference income have no effect. Furthermore, individuals weight upward comparisons more than downward comparisons. According to the rank hypothesis, income and utility are not directly linked: Increasing an individual’s income will only increase their utility if ranked position also increases and will necessarily reduce the utility of others who will lose rank

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12)

It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes. In contrast to the aerobic pathway, the anaerobic route has remained enigmatic because many of its intermediates have proven technically challenging to isolate, because of their inherent instability. However, by studying the anaerobic cobalamin biosynthetic pathway in Bacillus megaterium and using homologously overproduced enzymes, it has been possible to isolate all of the intermediates between uroporphyrinogen III and cobyrinic acid. Consequently, it has been possible to detail the activities of purified cobinamide biosynthesis (Cbi) proteins CbiF, CbiG, CbiD, CbiJ, CbiET, and CbiC, as well as show the direct in vitro conversion of 5-aminolevulinic acid into cobyrinic acid using a mixture of 14 purified enzymes. This approach has resulted in the isolation of the long sought intermediates, cobalt-precorrin-6A and -6B and cobalt-precorrin-8. EPR, in particular, has proven an effective technique in following these transformations with the cobalt(II) paramagnetic electron in the dyz orbital, rather than the typical dz2. This result has allowed us to speculate that the metal ion plays an unexpected role in assisting the interconversion of pathway intermediates. By determining a function for all of the pathway enzymes, we complete the tool set for cobalamin biosynthesis and pave the way for not only enhancing cobalamin production, but also design of cobalamin derivatives through their combinatorial use and modification

An Energy and Performance Exploration of Network-on-Chip Architectures

In this paper, we explore the designs of a circuit-switched router, a wormhole router, a quality-of-service (QoS) supporting virtual channel router and a speculative virtual channel router and accurately evaluate the energy-performance tradeoffs they offer. Power results from the designs placed and routed in a 90-nm CMOS process show that all the architectures dissipate significant idle state power. The additional energy required to route a packet through the router is then shown to be dominated by the data path. This leads to the key result that, if this trend continues, the use of more elaborate control can be justified and will not be immediately limited by the energy budget. A performance analysis also shows that dynamic resource allocation leads to the lowest network latencies, while static allocation may be used to meet QoS goals. Combining the power and performance figures then allows an energy-latency product to be calculated to judge the efficiency of each of the networks. The speculative virtual channel router was shown to have a very similar efficiency to the wormhole router, while providing a better performance, supporting its use for general purpose designs. Finally, area metrics are also presented to allow a comparison of implementation costs

The Smith Cloud: high-velocity accretion and dark-matter confinement

The Smith Cloud is a massive system of metal-poor neutral and ionized gas M_gas >= 2x10^6 M_sun) that is presently moving at high velocity (V_GSR ~300 km s^-1) with respect to the Galaxy at a distance of 12 kpc from the Sun. The kinematics of the cloud's cometary tail indicates that the gas is in the process of accretion onto the Galaxy, as first discussed by Lockman et al. (2008). Here, we re-investigate the cloud's orbit by considering the possibility that the cloud is confined by a dark matter halo. This is required for the cloud to survive its passage through the Galactic corona. We consider three possible models for the dark matter halo (NFW, Einasto, Burkert) including the effects of tidal disruption and ram-pressure stripping during the cloud's infall onto and passage through the Galactic disk. For the NFW and Einasto dark-matter models, we are able to determine reasonable initial conditions for the Smith Cloud, although this is only marginally possible with the Burkert model. For all three models, the progenitor had an initial (gas+dark matter) mass that was an order of magnitude higher than inferred today. In agreement with Lockman et al. (2008), the cloud appears to have punched through the disk ~70 Myr ago. For our most successful models, the baryon to dark matter ratio is fairly constant during an orbital period but drops by a factor of 2-5 after transiting the disk. The cloud appears to have only marginally survived its transit, and is unlikely to retain its integrity during the next transit ~30 Myr from now.Comment: 9 pages, 7 figures. ApJ, accepte

Topological Quantum Compiling

A method for compiling quantum algorithms into specific braiding patterns for non-Abelian quasiparticles described by the so-called Fibonacci anyon model is developed. The method is based on the observation that a universal set of quantum gates acting on qubits encoded using triplets of these quasiparticles can be built entirely out of three-stranded braids (three-braids). These three-braids can then be efficiently compiled and improved to any required accuracy using the Solovay-Kitaev algorithm.Comment: 20 pages, 20 figures, published versio

The Case for a Heat-Pipe Phase of Planet Evolution on the Moon

The prevalence of anorthosite in the lunar highlands is generally attributed to the flotation of less dense plagioclase in the late stages of the solidification of the lunar magma ocean. It is not clear, however, that these models are capable of producing the extremely high plagioclase contents (near 100%) observed in both Apollo samples and remote sensing data, since a mostly solid lithosphere forms (at 60-70% solidification) before plagioclase feldspar reaches saturation (at approximately 80% solidification). Formation as a floating cumulate is made even more problematic by the near uniformity of the alkali composition of the plagioclase, even as the mafic phases record significant variations in Mg/(Mg+Fe) ratios. These problems can be resolved for the Moon if the plagioclase-rich crust is produced and refined through a widespread episode of heat-pipe magmatism rather than a process dominated by density-driven plagioclase flotation. Heat-pipes are an important feature of terrestrial planets at high heat flow, as illustrated by Io's present activity. Evidence for their operation early in Earth's history suggests that all terrestrial bodies should experience an early episode of heat-pipe cooling. As the Moon likely represents the most wellpreserved example of early planetary thermal evolution in our solar system, studies of the lunar surface and of lunar materials provide useful data to test the idea of a universal model of the way terrestrial bodies transition from a magma ocean state into subsequent single-plate, rigid-lid convection or plate tectonic phases

An exploratory randomised controlled trial of a premises-level intervention to reduce alcohol-related harm including violence in the United Kingdom

<b>Background</b><p></p> To assess the feasibility of a randomised controlled trial of a licensed premises intervention to reduce severe intoxication and disorder; to establish effect sizes and identify appropriate approaches to the development and maintenance of a rigorous research design and intervention implementation.<p></p> <b>Methods</b><p></p> An exploratory two-armed parallel randomised controlled trial with a nested process evaluation. An audit of risk factors and a tailored action plan for high risk premises, with three month follow up audit and feedback. Thirty-two premises that had experienced at least one assault in the year prior to the intervention were recruited, match paired and randomly allocated to control or intervention group. Police violence data and data from a street survey of study premises’ customers, including measures of breath alcohol concentration and surveyor rated customer intoxication, were used to assess effect sizes for a future definitive trial. A nested process evaluation explored implementation barriers and the fidelity of the intervention with key stakeholders and senior staff in intervention premises using semi-structured interviews.<p></p> <b>Results</b><p></p> The process evaluation indicated implementation barriers and low fidelity, with a reluctance to implement the intervention and to submit to a formal risk audit. Power calculations suggest the intervention effect on violence and subjective intoxication would be raised to significance with a study size of 517 premises.<p></p> <b>Conclusions</b><p></p> It is methodologically feasible to conduct randomised controlled trials where licensed premises are the unit of allocation. However, lack of enthusiasm in senior premises staff indicates the need for intervention enforcement, rather than voluntary agreements, and on-going strategies to promote sustainability